Could eye movements provide a window into early signs of dementia? Investigating the relationship between eye movements and cognitive decline.
subject: saccades Alzheimers
description: Past research has indicated a relationship between eye movement abilities and cognitive decline. Specifically, performances on the anti-saccade task and pro-saccade task have demonstrated a correlation with Alzheimer’s disease (AD) severity, suggesting that impairments in visual ability may be a potential biomarker for dementia. However, little research has investigated whether the same deficiency is present in more ecologically valid tasks. The current study therefore aimed to extend the dementia literature by examining eye movement abilities in individuals with AD when completing a task that required the visual exploration of videos. In order to investigate a disease effect, patients with AD were compared to healthy older controls. To explore age effects, the older controls were additionally compared to healthy younger controls. To attempt to replicate previous findings, all groups first completed both the pro-saccade and anti-saccade task, before subsequently completing a video task designed to require similar abilities as those necessitated by the anti-saccade task. The findings revealed clear qualitative differences between the age effect and the disease effect on the anti-saccade task, suggesting that AD is not purely an accelerated form of ageing. Furthermore, the results supported the contemporary literature, in that, patients with AD made more errors, and less corrected errors, on the anti-saccade task. In turn, these results advocate for the utilisation of the task as a biomarker of AD. However, this impairment did not translate to the videos task. These results suggest that certain conditions may be conducive to normal viewing behaviour in patients with AD, and thus may potentially indicate that the natural exploration of videos is not a reliable biomarker for AD.
creator: Jennifer Grayling
source: For all saccade tasks, a repeated measures design was used, with group as the independent variable (AD, OC, and YC). For the PST there were 2 dependent variables: latency and amplitude (see appendix A for definitions). For the AST there were 5 dependent variables latency, amplitude, number of errors, corrected errors percentage, and corrected errors start time (see appendix B for definitions). For the videos a 3(Group: AD, OC, YC) x 2(Instructions: free view, instructed view) mixed design was used, with group as a between-subjects factor and instructions as a within-subjects factor. For each of the videos, dwell time was calculated as the dependent variable. A total of 25 AD, 17 OC and 37 YC completed the video task. Materials Eye tracking apparatus. An EyeLink Desktop 1000 eye-tracker was used at 1000Hz to record eye movements. Participants sat approximately 55cm away from the screen with their head on a chin rest to minimise movement. A 3x3 grid of sequentially appearing dots was used to calibrate participant’s dominant eye with the machine. Pro-saccade task. The PST provides a measure of involuntary responses to visual stimulus. The methods utilised in this study followed previously established procedures (Crawford et al., 2005). In order to centre the participant’s gaze, the trial commenced displaying a central fixation target for 1000 milliseconds. This target then disappeared for 200 milliseconds, before a peripheral target appeared for 2000 milliseconds either to the left or right of the initial central fixation target (at ± 4°). The direction was randomised in order to avoid predictive saccades. The inter-trial interval then took place for 1200 milliseconds. The next trial began when the central fixation point reappeared. The participant’s task was to look at the peripheral target as quickly and accurately as possible (see appendix C). There were 36 trials in total. Anti-saccade task. The AST provides a measure of inhibition. The task format was identical to…
publisher: Lancaster University
date: 2017
contributor: John Towse
rights: Open
relation: This is part of an on-going EPSRC funded MoDEM study approved by the NHS to Dr Crawford
format: data/SPSS.sav
language: English
type: Data
coverage: LA1 4YF

Experiencing social acceptance and rejection through ‘likes’ and ‘dislikes’: Does sleep quality affect the processing of social rewards?
subject: Adolescence Pupil dilation Social feedback Reward Rejection Sleep debt.
description: In adolescence, high importance is placed on peer evaluations and social rewards have increased salience during this developmental period. Sleep patterns also change in adolescence, as teenagers typically experience insufficient sleep. This research measured the pupil dilation of forty-four adolescents aged 16 to 18 using two tasks (audio and visual) to investigate whether sleep duration influenced the way social acceptance and rejection were processed. Sleep duration scores were obtained using the measure of sleep debt; this was calculated by subtracting sleep duration during the week from sleep duration at the weekend, plus weekday bedtime. It was expected that higher sleep debt would be linked to increased pupil reactivity towards social feedback and that there would be a greater pupil dilation in response to social rejection compared to social acceptance. In the visual task, it was found that sleep debt affected males and females differently when processing social rewards, as females with high sleep debt showed increased pupil dilation towards positive feedback compared to negative feedback, whereas males with low sleep debt showed a larger dilation towards positive feedback than females. It was also found that females with lower sleep debt gave more likes than dislikes when rating photos. This implies that sleep duration affects the social feedback adolescents provide. When a male voice was used in the audio task, more pupillary reactivity towards social acceptance was observed, however when a female voice was used, pupils dilated more in response to social rejection. Future research should further investigate these gender differences.
creator: Abigail Taylor-Spencer
source: Participants Forty-four participants (N=44) were recruited from Haslingden High School and Sixth Form to participate in this research. The participants (35 female, 9 male) were all between the ages of 16 and 18 (Mage = 16.98, SDage = .63). Students in Psychology, Sociology and English classes were given the opportunity to participate in the research and contacted the researcher via email if they wished to participate. Each participant provided their informed consent before beginning the study. Materials Photo ratings. Firstly, the participants were shown a PowerPoint containing 40 photos, which had been previously collected by the researcher, and featured adolescents which the participants did not know. Each photo was displayed individually for four seconds, meaning that the presentation lasted two minutes and forty seconds in total. Participants were provided with a sheet of paper on which they had an option to tick either ‘like’ or ‘dislike’ for each photo on the PowerPoint (see Appendix A). The total number of likes was calculated for each participant. Eye tracker. An eye-tribe desktop eye tracker with a 30Hz sampling rate was used to measure the pupil dilation of the participants in response to stimuli on two tasks - a visual task and an audio task. A chin rest was used to ensure the participants kept their heads still. Visual task. The visual task involved showing the participants the same 40 photos which they had previously been shown in the photo rating task, however, each photo had either a ‘like’ symbol or ‘dislike’ symbol (see Figure 1) in the bottom right hand corner. Participants were informed prior to beginning the task that if a photo contained the ‘like’ symbol, it meant that the individual in the photo had liked the participant’s picture, however the ‘dislike’ symbol meant that the individual in the photo had disliked the participant’s picture. The presentation of photos was randomised across participants Audio task. The audio task involved the parti…
publisher: Lancaster University
date: 2018
contributor: Ellie Ball
rights: Open
relation: None
format: data/SPSS.sav
language: English
type: Data
coverage: LA1 4YF

Infants' Awareness of Number: Innate Ability or Perceptual Bias?
subject: Addition, subtraction, Number, Object Tracking, object files, Infant perception
description: In order to identify the origin of our understanding of numerosity and arithmetic abilities, it is essential that such abilities are measured in infants. In Wynn’s (1992) study, a case was made for an innate ability to perform arithmetic operation on small number sets as it was demonstrated that infants would look longer at displays that violated their expectations of number. However, research in the years following this seminal study cast doubt on this interpretation of infants’ behaviour. Other research has suggested that perceptual biases are at play, rather than infants possessing a symbolic understanding of number. To address the contrasting finding in this area of developmental research, this study set out to analyse preexisting data to investigate the factors that influence infants’ abilities to track objects over occlusion and to identify the most appropriate level of interpretation of this ability The present study recruited a sample of 32 infants across two experiments. Adapting the methodology from Wynn (1992), Experiment 1 measured looking time when an object was revealed to be missing from the display, violating infants’ expectation of presence. Experiment 2 measured looking time when an object was revealed to be in the incorrect position on the stage, violating infants’ expectation of position. It was found that infants violation trial had a significant effect on looking time and whether the object missing was the first or last to be placed had a significant effect on looking time in violation of presence conditions
creator: Jessica Sparks
source: Participants: In this study, participants were 32 infants aged 5- to 7-months, (M = 188.38 days, SD = 10.51, range = 175 – 218). Infants were 15 males and 17 females. 16 participants were used in each experiment. In Experiment 1, participants were 7 males and 9. In Experiment 2, participants were 8 males and 8 females. Participants in each experiment were matched based on age. Apparatus & Stimuli: The experiment took place in a dimly lit test room, with displays presented on a grey stage measuring 64cm wide by 40cm high and 31cm deep. An 8.5cm high black screen located 31.5cm behind the front of the stage was used to occlude the display by being rotated upwards. The display also consisted of a 30cm rotating platform that allowed different configurations of objects to be rotated rapidly. The objects used in this study were two 12.5cm high by 9.5cm wide toy hedgehogs that squeaked when squeezed. These toys were magnetic at the bottom. Procedure: Infants were sat in either a high seat or on a caregiver’s lap, 60cm from the front edge of the stage. In cases where infants were sat on a caregiver’s lap, the caregiver’s eyes were above the stage as to avoid them seeing the display and possibly influencing the infant’s behaviour. After gaze calibration to ensure the accuracy of eye-tracking measures, the procedure closely followed that of Wynn (1992) and Bremner et al (2017). Three pre-test (baseline) trials were presented initially. These resulted in the correct outcome of the operation as well as the two incorrect outcomes in counterbalanced order. The screen was lowered to reveal either one or two toys, depending on the trial, and the observer recorded where the infant looked on the stage. In terms of the location of the toys in trials, when one was presented, it was placed 7.5cm to the right of the stage’s centre. When two toys were presented, the second toy was placed 7.5cm to the left of the stage’s centre. Pre-test trials continued until the infant accumulated at lea…
publisher: Lancaster University
date: 07.09.2021
contributor: Julonna Peterson and Rebecca Mitchell
rights: open
relation: Wynn's 1992 study
format: .csv
language: English
type: Data
coverage: Developmental

Lights, Camera, Action: Investigating Advertisement Susceptibility in Films Amongst Individuals with Parkinson’s Disease and Controls.
subject: Parkinson’s Disease, Inhibitory Control, Product Placement Susceptibility
description: Product placement is the merging of entertainment with advertising, and its presence in our daily lives is increasing. Despite this, there is an inherent lack of consideration of its influence amongst vulnerable populations such as individuals with Parkinson’s disease (PD). Research suggests that individuals with PD have reduced inhibitory control (IC) which may drive impulsive behaviours. A concernment, therefore, is the influence that product placement may have on the purchase behaviour of individuals with PD alongside a possible propensity to partake in risky and impulsive behaviours. Thus, this study aimed to examine whether reduced IC increases the likelihood that an individual with PD will be susceptible to product placement. The study adopted an experimental approach, recruiting 20 healthy younger controls, 20 healthy older controls, and 13 individuals with mild to moderate PD to participate in watching two films containing product placement; one featuring Coca Cola and the other an Audi. A pre and post product placement questionnaire was used to measure change in purchase behaviour before and after exposure to product placement, and an antisaccade eye tracking task and a Stroop task was used to measure IC. An ANOVA indicated that IC was significantly impaired in individuals with PD compared to healthy controls. Despite this, linear mixed effects modelling suggested that IC may not be a factor that increases the likelihood that an individual will be more susceptible to product placement. Implications of these findings are discussed relative to other clinically vulnerable populations with similar cognitive impairment symptomology, and the consequent need for future research to continue to explore product placement susceptibility amongst vulnerable populations.
creator: Elena Ball
source: Method Participants A voluntary sample of 54 participants were recruited, 20 healthy younger controls (YC) (16 females and four males, (Mage= 22.70, SDage= 2.42)), 20 healthy older controls of comparable age to those with Parkinson’s (OC) (females and males, (Mage= 66.85, SDage= 8.53)), and 15 adults with mild-moderate idiopathic PD (females and males, (Mage= 65.00, SDage= 7.84)). As this research area is entirely novel this sample size was modelled on comparable population studies that have explored IC (Meyer et al., 2020; Paz-Alonso et al., 2020). YC were defined as young adults aged between 18 to 26 years old with no neurological or cognitive conditions (Stroud et al., 2015). OC were defined as adults aged between 50 to 85 years old with no neurological or cognitive conditions (Zhang et al., 2020). The participants with PD had been diagnosed with mild-moderate idiopathic PD, characterised by mild-moderate impairments of motor and cognitive functioning (DeMaagd & Philip, 2015). The exclusion criteria for both the healthy controls and individuals with PD were those who had a diagnosis of any additional neurological or cognitive conditions other than PD. Moreover, given that visual impairments may affect the visual experience of product placement, all participants were screened for red-green colour blindness using the Ishihara test. The standardised cut off for normal vision is 15 (Rodriguez-Carmona & Barbur, 2017), therefore, participants who score 14 or less were excluded as this is indicative of the presence of red-green colour blindness. All participants had normal or corrected-to-normal vision. The Addenbrooke’s Cognitive Examination-III (ACE) was used to screen for the presence of cognitive impairment (Bruno & Vignaga, 2019). Participants’ data was only included in analysis if participants achieved a score within the normal range (≥ 82 out of 100). Following this exclusion criteria, one PD participant’s data was removed. Research has shown saccadic eye movemen…
publisher: Lancaster University
date: 07.09.2022
contributor: Elena Ball
rights: Open
relation: N/A
format: Data/R.csv
language: English
type: Data
coverage: LA1 4YF

Eye tracking and Attention Deficit Hyperactivity Disorder (ADHD): Can eye tracking identify the feigning of ADHD?
subject: Eye-tracking, ADHD, Feigning, Prosaccade task, Anti-saccade task, latency, error rate, eye movements
description: When diagnosing adult ADHD, it has proven difficult for clinicians to detect deceptive behaviour. Diagnosis of ADHD comes with economic, academic, and recreational benefits, which may account for the increasing feigning of the disorder. Current diagnostic methods: clinical interviews and self-report scales can be easily manipulated for a positive diagnosis. Hence the present study evaluated the utility of eye tracking devices to detect the feigning of ADHD. Eye movements of 38 participants (7 ADHD, 15 healthy controls, and 16 healthy feigners) were captured throughout the prosaccade and anti-saccade task. The performance of the participants on the task was evaluated in terms of latency and the percentage of error rate. The findings of the study reveal a significant difference in the latency of anti-saccade tasks i.e., feigners have an increased latency compared to healthy controls and ADHD participants. Because of the limited sample size, study findings cannot be generalized. Further investigations are needed with a much larger sample.
creator: Reva Maria George
source: Method Participants Previous studies explaining feigning in ADHD acquired data from around 90-100 samples (Booksh et.al., 2010; Frazier et.al., 2008; Harrison et.al., 2007). The study therefore aimed to recruit 90 participants, 30 each in ADHD, healthy controls, and healthy feigners faking the disorder. Participants with and without a clinical diagnosis of ADHD were selected using the opportunity sampling method. A total of 42 participants between the age of 18-35 volunteered and were recruited for the study through the university disability service (11%), posters (16%) and through word of mouth (73%). Data of two participants were removed as the eye tracker repeatedly lost the pupil during recording. All participants were rewarded with an equal chance to win one of 6 £25 vouchers. Thirty-one of the 42 participants were healthy younger adult controls. Of the healthy control participants 15 (7 females; Mage = 24.33; SDage=4.32) participated as healthy controls, and the remaining 16 (9 females; Mage = 24.25; SDage=1.88) as healthy feigners. Seven ADHD participants (6 females) with a mean age 22.71 (SD=2.22) completed the study. The severity of the ADHD symptoms was analysed using the Adult ADHD self-report scale (for more demographic details see Table 1). The exclusion criteria include participants: 1) with any visual (other than corrected-to-normal vision) impairment 2) with any cognitive impairment 3) with additional diagnosis of neurological conditions 4) without a proper clinical diagnosis of ADHD. The exclusion criteria were applied because these impairments may interfere with the participants performance in the task. Prior to data analysis, one of the participants was removed from ADHD group due to the lack of proper clinical diagnosis. Furthermore, a control participant was excluded with the assumption of having a probable mild cognitive impairment because the individual scored less than 82 (cut-off) in the Addenbrooke’s Cognitive Examination-III (ACE-III) (see…
publisher: Lancaster University
date: 7/09/2022
contributor: Lettie and Delyth
rights: Open
relation: None
format: SPSS.sav for results Word.doc for demographic and data acquistion form PDF for consent form
language: English
type: Data and Text
coverage: LA1 4YF

Levodopa and antisaccade performance in Parkinson’s disease: the influence of intrinsic dopaminergic functioning, dopamine agonists and chronic anti-parkinsonian medication
subject: Keywords: Parkinson’s disease, dopamine overdose hypothesis, spontaneous eye blink rate, levodopa, dopamine agonists, antisaccade
description: The antisaccade (AS) task is a validated eye-tracking paradigm primarily used to assess response inhibition. Although several studies have established AS error rate and latency to be increased in Parkinson’s disease (PD), the evidence regarding the effect of existing anti-parkinsonian medication (e.g., levodopa) on these parameters is contradictory. According to the dopamine overdose hypothesis (DOH), the effect of levodopa on AS performance should be dependent upon the intrinsic dopaminergic functioning of the individual. The current study is the first study to use spontaneous eye blink rate (SEBR), a proxy measure for dopamine activity, to investigate the influence of intrinsic dopaminergic functioning on AS performance following levodopa consumption. The influence of additional PD related factors was also examined. SEBR and AS performance was assessed in eleven healthy controls (HC) and nine participants with PD. SEBR and AS performance was assessed twice in participants with PD, once 30 minutes prior to, and once one hour after, the consumption of levodopa. Pre-levodopa consumption SEBR was a significant positive predictor of AS error rate post, but not pre, levodopa consumption. Total years consuming anti-parkinsonian medications was positively predictive of AS error rate both pre and post levodopa consumption. The regular consumption of dopamine agonists was found to significantly predict fewer AS errors following the consumption of levodopa. The current results support the DOH; higher intrinsic dopaminergic functioning was associated with increased AS errors following the artificial stimulation of dopamine via by levodopa. Therefore, artificial dopaminergic stimulation of an intrinsically sufficiently functioning dopaminergic system appears to produce an overstimulation/overdose effect whereby consequential detrimental effects on AS performance/response inhibition are observed. The current findings go some way in explaining the inconsistencies within the lite…
creator: Amy Austin
source: Twenty-one participants, 10 individuals with mild-moderate idiopathic PD (Mage = 67.10, SDage = 8.63) and 11 healthy control older adults of comparable age (HC; Mage = 66.82, SDage = 9.09) were recruited to the study. The mean age of recruited HC and PD individuals did not differ significantly, t (18.95) = - 0.07, p = .943). Participants were recruited via established research databases and via the social network of the researcher. As the current study focused on PD, participants with a diagnosis of any neurological conditions (beyond PD) were excluded. Additionally, as depression and anxiety influence an individual’s saccadic performance profile and SEBR (Jazbec et al., 2005; Mackintosh et al., 1983), individuals who obtained a clinically moderate depression or anxiety score, as measured by the Hospital Anxiety and Depression scale (HADS), were excluded. Similarly, mild cognitive impairment (MCI) and dementia are associated with increased AS error rate and AS latency (Opwonya et al., 2022), and increased SEBR (D’Antonio et al., 2021). As such, those who presented a cognitive profile indicative of MCI/dementia (score < 82 on the Addenbrookes Cognitive Exam-III, ACE-III; Hsieh et al., 2013) were excluded from the current study. Finally, as experimental stimuli in the current study were coloured red and green, individuals with red-green colour vision deficiency, detected via the Ishihara test (Ishihara, 1917) were also excluded. On these grounds of exclusion, one individual with PD was excluded from the current study due to obtaining an ACE-III score indicative of MCI. Subsequently, nine individuals with mild-moderate idiopathic PD (Mage = 65.89, SDage = 8.21) and eleven HC individuals (Mage = 66.82, SDage = 9.09) participated in the study. All participants had normal or corrected to normal vision. All participants with PD were classified as Hohen and Yahr stage II or below (Hoehn & Yahr, 1998), indicating they were physically independent and capable of completing all…
publisher: Lancaster University
date: 14th September 2022
contributor: Rachel Jordan Sian Reid
rights: Open
relation: N/A
format: Data/R.csv
language: English
type: Data
identifier: Austin 2022
coverage: LA1 4YF